Fatty Acids Metabolism: The Bridge Between Ferroptosis and Ionizing Radiation

Fatty Acids Metabolism: The Bridge Between Ferroptosis and Ionizing Radiation

Blog Article

Exposure of tumor cells to ionizing radiation (IR) alters the microenvironment, particularly the fatty acid (FA) profile and activity.Moreover, abnormal FA metabolism, either catabolism or anabolism, is essential for synthesizing biological membranes and delivering molecular signals to induce ferroptotic cell death.The current Player Bag review focuses on the bistable regulation characteristics of FA metabolism and explains how FA catabolism and anabolism pathway crosstalk harmonize different ionizing radiation-regulated ferroptosis responses, resulting in pivotal cell fate decisions.In summary, targeting key molecules involved in lipid metabolism and ferroptosis may BONE BROTH GRASS-FED BEEF amplify the tumor response to IR.